Vibrant America Testing
A proprietary line of peptide-level tests for thousands of peptides in commonly antigenic foods, with higher accuracy than standard food sensitivity testing. These tests are designed to help customize and personalize diet recommendations when addressing complicated conditions such as intestinal permeability and autoimmune diseases, in order to avoid one-size-fits-all elimination protocols that may be unnecessarily limiting, or even harmfully add reactive foods, in some cases.
o The Wheat Zoomer: Vibrant’s flagship peptide-level test with the most robust panel available for the detection of intestinal permeability, gluten- and wheat-sensitivity, celiac disease, and gluten-mediated autoimmunity. Click here for Sample Report.
o Celiac Genetics: Celiac disease tests are ordered when someone has signs and symptoms suggesting celiac disease, malnutrition, and/or malabsorption. The symptoms are often nonspecific and variable, making the disease difficult to spot. The symptoms may be mild for some time, going unnoticed, and then progressively worsen or occur sporadically.
Profile 1 - 96 foods: Click here for Sample Report 1
The test panel includes 96 of the most common allergens as listed below. Testing can also be done individually on each item listed.
o Neural Zoomer: A tool to detect the most common autoantibodies associated with neurological autoimmunity and cognitive decline.
o Neural Zoomer APO E Add on: The Apo E Add on is the Neural Zoomer optional additional genetic testing for the Apo E genotype, which has been shown to influence risk for certain neurological conditions.
o The Gut Zoomer: A PCR-based test for screening over 110+ bacteria, including pathogens, in addition to intestinal parasites, Candida, and viruses; relative abundances are displayed at the phylum, family, genus, and species level, and correlated to medical condition risk. Click here for Sample Report.
o Heavy Metals: To test for and identify heavy metal toxicity from 20 of the most common heavy metals. Click here for Sample Report
o IBSSure: A screening tool for antibodies that are associated with the autoimmune breakdown of the migrating motor complex (MMC), which can result in the development of refractory SIBO. Click here for Sample Report.
o Cardiax: A health analytics tool for the detection of genetic polymorphisms associated with cardiovascular disease, hypertension, diabetes, insulin resistance, atrial fibrillation, stroke and dyslipidemia. Click here for Sample Report.
o Mycotoxins: To test for the presence of toxic mold exposure. Click here for Sample Report.
o Egg Component: A test for detection of allergic response to egg components. What is the difference between the Egg Component test and the Egg Zoomer? The Vibrant Egg Component test is a screen for allergic reactions or allergic sensitization to egg peptides and components, which involve IgE antibodies to the measured peptides. The Vibrant Egg Zoomer is a test for sensitivity to egg peptides, which involve IgG and IgA antibodies, and which are not allergic sensitivities.
o Peanut Component: A test for detection of peanut allergies to peanut components.
o Tickborne Diseases: A test for detecting Lyme and other tickborne diseases through both antigen testing and PCR recognition of microorganisms at a highly accurate level for definitive data in making diagnostic decisions. Click here for Sample Report 1
o Anti-Aging: Micronutrient and Hormone Panel
o Anti-Aging Advanced: Hormone panel, 96 Food Sensitivity, 4 Food Zoomer Bundle, Micronutrients and Neural Zoomer Plus
o Micronutrient: A one-of-a-kind nutritional screening tool to assess direct measurement of both intra- and extracellular nutrient status of common vitamins, minerals, co-factors, amino acids, essential fatty acids and more. The only test that provides a comprehensive extracellular and intracellular assessment of the levels of the most important vitamins, minerals, antioxidants, fatty acids and amino acids. Click here for Sample Report. Testing can also be done individually an all listed below:
The test panel includes 46 of the most common allergens, including different types of mites, molds, animal dander, weeds, grasses, insects, trees, and shrubs. Testing can also be done individually an all listed below:
Celiac disease tests are ordered when someone has signs and symptoms suggesting celiac disease, malnutrition, and/or malabsorption. The symptoms are often nonspecific and variable, making the disease difficult to spot. The symptoms may be mild for some time, going unnoticed, and then progressively worsen or occur sporadically. These tests can be run individually:
o Vibrant™ Anti-dGP IgG
o Celiac HLA Genetics
Includes the genes associated with celiac disease.
o HLA (DQ2 and DQ8) genotyping with relative risk assessment.
o Vitamin D, 25-OH+
Vibrant America offers a complete hormone testing menu that is essential to evaluating and determining your overall health and well being.
Hormones play an important role in women’s health.
Estrogen and progesterone are probably the most important hormones when evaluating reproductive health.
In addition to these sex hormones, your body also makes and uses other important hormones that can have an effect on your overall health, such as your energy level, weight, mood, and sleep patterns. Tests Offered:
This is the adrenal “stress hormone” that is elevated with both physical or emotional stressors and it plays a role in the metabolism of proteins, lipids, and carbohydrates.
To measure or monitor your estrogen levels; to detect an abnormal level or hormone imbalance; to monitor treatment for infertility or symptoms of menopause.
Regulate and stimulate the growth and function of the ovaries and is used to evaluate fertility issues and function of other reproductive organs.
To help determine the cause of infertility, track ovulation, help diagnose an ectopic or failing pregnancy, monitor the health of a pregnancy, monitor progesterone replacement therapy, or help diagnose the cause of abnormal uterine bleeding.
In women is useful in the determination of risk for cardiovascular disease but the most frequent cause of elevated testosterone levels, is polycystic ovarian syndrome, however high levels are also associated with insulin resistance, abdominal obesity, abnormal lipids, and chronic inflammation.
Produced by the liver, SHBG is a protein that is tightly bound to testosterone, estrogen and DHT. SHBG is a mechanism for transporting these hormones in inactive form. These levels can effect the amount of testosterone that is used by the body’s tissues.
There are 3 major biologically active estrogens in humans: estrone (E1), estradiol (E2), and estriol (E3). Most of the circulating E1 is derived from peripheral aromatization of androstenedione (mainly adrenal). E2 and E1 can be converted into each other, and both can be inactivated via hydroxylation and conjugation. E2 demonstrates 1.25 – 5s times the biological potency of E1. E2 circulates at 1.5 – 4 times the concentration of E1 in premenopausal, nonpregnant women. E2 levels in men and postmenopausal women are much lower than in nonpregnant women, while E1 levels differ less, resulting in a reversal of the premenopausal E2:E1 ratio.
There are 3 major biologically active estrogens in humans: estrone (E1), estradiol (E2), and estriol (E3). During pregnancy, E3 becomes the dominant estrogen. The fetal adrenal gland secretes dehydroepiandrosterone-sulfate (DHEAS), which is converted to E3 in the placenta and diffuses into the maternal circulation. The half-life of unconjugated E3 (uE3) in the maternal blood system is 20 to 30 minutes, since the maternal liver quickly conjugates E3 to make it more water soluble for urinary excretion. E3 levels increase throughout the course of pregnancy, peaking at term.
Prolactin is a hormone that is best known for its role in enabling milk production. It is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation and nursing. Prolactin plays an essential role in metabolism, regulation of the immune system and pancreatic development. The hormone counteracts the effect of dopamine. Elevated levels of prolactin decrease the levels of sex hormones — estrogen in women and testosterone in men. The effects of mildly elevated levels of prolactin are much more variable, in women, substantially increasing or decreasing estrogen levels.
Pregnenolone is the first steroid to be derived from cholesterol in the pathway of steroidogenesis, and it is the common precursor for all of the adrenal and gonadal steroids. Its production occurs in the mitochondrion by cleavage of the C-20 side chain of cholesterol by the P-450SCC enzyme. Once produced, pregnenolone may be utilized by two pathways of steroidogenesis. Pregnenolone may either be converted to 17-OH pregnenolone via the enzymatic action of 17α-hydroxylase or to progesterone via the enzymatic action of 3β- hydroxysteroid dehydrogenase.
DHT is an endogenous androgen sex steroid and hormone. DHT is biologically important for sexual differentiation of the male genitalia during embryogenesis, maturation of the penis and scrotum at puberty, growth of facial, body, and pubic hair, and development and maintenance of the prostate gland and seminal vesicles. It is produced from the less potent testosterone by the enzyme 5α-reductase in select tissues, and is the primary androgen in the genitals, prostate gland, seminal vesicles, skin, and hair follicles.
o Factor II-V
In the U.S., every 34 seconds, someone has a heart attack and every 60 seconds, someone dies from a heart disease-related event.
Heart disease refers to a variety of conditions that affect the heart—from infections to genetic defects and blood vessel diseases. Most heart disease can be prevented with a healthy lifestyle, yet it’s the number-one health threat in the world, so it’s important that your know your cardiovascular numbers. Vibrant America offers the most relevant tests available to assess your risk or for monitoring current conditions.
Heart disease is the leading cause of death for both men and women, and compared to men, women are just as likely to have a heart attack. However, more women than men die from heart disease each year and women are more likely than men to die after their first heart attack.
Total serum cholesterol analysis is useful in the diagnosis of hyperlipoproteinemia, atherosclerosis, hepatic and thyroid diseases, as well as the risk of developing cardiovascular disease.
HDL (the “healthy” or “good” cholesterol) is inversely related to the risk for cardiovascular disease. It increases following regular exercise, moderate alcohol consumption and with oral estrogen therapy. Decreased levels are associated with obesity, stress, cigarette smoking and diabetes mellitus.
LDL is the “bad” cholesterol. Even within the normal range of total cholesterol concentrations, an increase in LDL cholesterol can produce an associated increased risk for cardiovascular disease. LDL cholesterol binds to receptor sites on macrophages in blood vessel walls inciting several changes to the blood wall which enhance atherosclerotic plaque development.
Triglycerides are fats from the food we eat that are carried in the blood. Most of the fats we eat, including butter, margarine and oils, are in triglyceride form. Excess calories, alcohol or sugar in the body turn into triglycerides and are stored in fat cells throughout the body. This test will measure the amount of triglycerides in the blood.
Apo A-1 represents the “good” cholesterol, so higher levels are best. Apolipoprotein A-1 (Apo A-1) has been reported to be a better predictor than HDL cholesterol and triglycerides for coronary artery disease. Low levels of Apo A-1 in serum are associated with increased risk of coronary artery disease. Measurement of Apo A-1 may be of value in identifying patients with atherosclerosis.
Apo B represents the “bad” cholesterol, so lower levels are best. Apo B is the main structural component of the non-HDL lipoproteins, including VLDL, IDL, LDL and Lp(a). Each Apo B molecule is attached to one LDL particle and is therefore more representative of actual atherogenic particles than LDL, which represents cholesterol content of lipoproteins.
The PLAC® Test for Lp-PLA2 activity measures the function of Lp-PLA2 in the artery wall— a vascular-specific inflammatory marker critical in the formation of rupture-prone plaque. Lp- PLA2 activity is a novel risk predictor in people with no prior history of cardiovascular events with a prognostic value independent of standard lipid profile testing. The greater the Lp-PLA2 Activity, the greater the risk of fatal and non-fatal coronary heart disease (CHD) events. A PLAC test may sometimes be used along with an hs-CRP test to evaluate a person’s level of underlying inflammation associated with Cardiovascular Disease (CVD) risk. However, unlike hs-CRP, the PLAC test is not affected by conditions other than CVD that can cause general inflammation, so it may be used when someone has an inflammatory condition, such as arthritis.
Homocysteine may be ordered as part of a screen for people at high risk for heart attack or stroke. It may be useful for someone who has a family history of coronary artery disease but no other known risk factors such as smoking, high blood pressure, or obesity. It may be an early indicator of Vitamin B12 and Folate deficiency, even before those tests show abnormal results.
C-reactive protein (CRP) is a protein that the liver makes when there is inflammation in the body. It’s also called a marker of inflammation, and can be measured with an hs-CRP (high-sensitivity C-reactive protein) test. Inflammation is a way for the body to protect itself from injuries or infections, and inflammation can be caused by smoking, high blood pressure, and high blood sugar. Excessive inflammation has been linked to heart disease.
Oxidized LDL is LDL cholesterol (the “bad” cholesterol) that has been modified by oxidation. Oxidized LDL triggers inflammation leading to the formation of plaque in the arteries, also known as atherosclerosis. Oxidized LDL may also play a role in increasing the amount of triglycerides the body produces, as well as increasing the amount of fat deposited by the body. In turn, fat tissue can enhance the oxidation of LDL, creating a vicious cycle.
Myeloperoxidase (MPO) enzyme is found in neutrophil primary granules and monocyte lysosomes. MPO catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. MPO is encoded by a single gene that undergoes posttranslational modification to produce the active enzyme found in leukocytes.
NT-proBNP is primarily secreted from the cardiac ventricular myocytes in response to cardiac stress. NT-proBNP is a useful diagnostic and prognostic tool as elevated levels may indicate the presence of an underlying cardiac disorder.
Small dense low-density lipoprotein transports cholesterol and triglycerides throughout the body. The smaller the particles, the more likely it is that they will get “stuck” in the artery wall, thus forming a build-up. A high result may indicate that a patient is at risk for cardiovascular disease. Lower numbers may indicate that you have fewer large “fluffy” particles, which are less likely to get stuck in the wall of the arteries.
Elevated Lp(a) is an inherited condition for four different types of vascular disease: CAD (coronary artery disease), PVD (peripheral vascular disease), ischemic stroke, and AAA (abdominal aortic aneurysm). Lp(a) is very resistant to treatment and it is important to aggressively treat all associated atherogenic lipoprotein abnormalities.
Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs) with a double bond (C=C) at the third carbon atom from the end of the carbon chain. The three types of omega-3 fatty acids involved in human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). The American Heart Association and the European Society for Cardiology recommend dietary intake of omega-3 fatty acids to reduce cardiovascular disease risk. In contrast to omega-3 fatty acids, omega-6 fatty acids (eg, arachidonic acid [AA]) and their metabolites are more proinflammatory than anti-inflammatory. Increased consumption of omega-6 fatty acids in place of saturated fats and trans fats is associated with a decreased risk of coronary heart disease.
Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes from the food you eat. Insulin, a hormone made by the pancreas, helps glucose from food get into your cells to be used for energy. Sometimes your body doesn’t make enough—or any—insulin or doesn’t use insulin well. Glucose then stays in your blood and doesn’t reach your cells. Over time, having too much glucose in your blood can cause health problems. Although diabetes has no cure, you can take steps to manage your diabetes and stay healthy.
BETA CELL FUNCTION
Connective Tissue Disorder
Connective tissue disorder (CTD) is a group of medical diseases that has the connective tissues of the body as a primary target of pathology.
Most CTDs feature abnormal immune system activity with inflammation in as a result of an immune system that is directed against one’s own body tissues (autoimmunity). Tests Offered:
o ANA IFA
o ENA 11 Profile (testing antibodies for SSA(Ro), SSB(La), RNP/Sm, Jo-1, Sm, Scl-70, Chromatin, Centromere, Histone, RNA polymerase III and dsDNA)
o Free T3
o Free T4
o CBC w/diff. and platelets
SCREENING (ABN REQUIRED)
o PSA Screen (once per year)
o Cardiovascular Screen (once every 5 years)
o Electrolytes, Glucose, BUN, Creatinine, Calcium
o Electrolytes, Glucose, BUN, Creatinine, Calcium, Albumin, Bil. Total, ALK, Total Protein, ALT, AST
o Bili, Total
o Protein, Total
o Bili, Direct
Renal Function Panel
A renal panel is ordered as a screening tool to evaluate kidney function. It provides information on the current status of the kidneys, electrolyte balance, acid/base balance, and blood sugar levels.
This test measures the amount of PSA in the blood. The PSA test is used as a tumor marker to screen for and to monitor prostate cancer.
o PSA, Total
o PSA, Free
o Total IGg
o Creatine Kinase
o CoQ10, Total
o Total IgM
o Uric Acid
o Cystatin C
o Fatty Acids (Omega 3 and 6)
o Immature Platelet Fraction
o Erythrocyte Sedimentation Rate
o Microalbumin, Urine